Detecting qualitative changes in biological systems

Cooperativity in biological systems

Living organisms can sense and respond to external and internal stimuli. Response isdemonstrated in many forms including modulation of gene expression profiles, motility,secretion, cell death, etc. Nevertheless, all forms share a basic property: they depend on sensingsmall changes in the concentration of an effector molecule or subtle conformational changes ina protein and invoking the appropri...

Detecting Changes in Scenes

cooperativity in biological systems

living organisms can sense and respond to external and internal stimuli. response isdemonstrated in many forms including modulation of gene expression profiles, motility,secretion, cell death, etc. nevertheless, all forms share a basic property: they depend on sensingsmall changes in the concentration of an effector molecule or subtle conformational changes ina protein and invoking the appropri...

An abstraction theory for qualitative models of biological systems

Multi-valued network models are an important qualitative modelling approach used widely by the biological community. In this paper we consider developing an abstraction theory for multi-valued network models that allows the state space of a model to be reduced while preserving key properties of the model. This is important as it aids the analysis and comparison of multi-valued networks and in p...

Learning Qualitative Models of Physical and Biological Systems

We present a qualitative model-learning system, Qoph, developed for application to scientific discovery problems. Qoph learns the structural relations between a set of observed variables. It has been shown capable of learning models with intermediate (unmeasured) variables, and intermediate relations, under different levels of noise, and from qualitative or quantitative data. A biological appli...